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Fosphenytoin iv to phenytoin po

Overview
After IV Cerebyx administration to patients with renal and/or hepatic disease, or in those with hypoalbuminemia, fosphenytoin clearance to phenytoin may be increased without a similar increase in phenytoin clearance. This has the potential to increase the . Fosphenytoin (Cerebyx) and mgPE. Fosphenytoin (Cerebyx) is a more water-soluble prodrug form of phenytoin that allows for faster IV infusion and less risk of extravasation injury. Because its molecular weight is different than that of phenytoin, one milligram of fosphenytoin does not equal one milligram of phenytoin. Pharmacokinetics of same PO and IV doses are similar. Oral bioavailability about 80%. 1,6 phenyTOIN mg IV Q8H mg PO daily When to PO give total IV daily dose once daily Oral bioavailability greater than 90% 1,2 methylPREDNISolone sodium variable predniSONE variable dose PO daily. 1. Fosphenytoin is dosed in phenytoin equivalents (PE) 1 PE fosphenytoin = 1 mg phenytoin sodium = mg fosphenytoin sodium. 2. Total body weight (TBW) is defined as the actual total mass of the patient in kilograms. Introduction. Fosphenytoin is a water soluble prodrug of phenytoin which is rapidly converted toFile Size: 1MB. Pantoprazole 40 mg IV any frequency Esomeprazole 20 mg PO same frequency Fosphenytoin*ⱡ Any dose IV any frequency Phenytoin same dose PO same frequency Thiamine mg IV any frequency mg PO same frequency *Hold continuous tube feeds as outlined in Hospital Policy #, Food-Drug Interactions, if needed. Phenytoin and now fosphenytoin are probably the most frequently used anticonvulsants for SE. The older formulation (phenytoin in a basic solution ethylene glycol) is still used because its cost is substantially lower. However, intravenous phenytoin has three major disadvantages: A longer time is required to achieve therapeutic levels. Short-term substitution for PO phenytoin. Can be substituted for PO phenytoin therapy at the same total daily dose; however, Dilantin capsules are 90% bioavailable PO while fosphenytoin is %. should have IV defined by one of the size at least as large as the antecubital fossa vein, 20 gauge or larger catheter size, or central line. If phenytoin is to be administered intravenously for greater than 48 hours a central line should be considered. In the absence of good venous fosphenytoin should.

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Pharmacotherapy Update | Fosphenytoin (Cerebyx®)

1. Fosphenytoin is dosed in phenytoin equivalents (PE) 1 PE fosphenytoin = 1 mg phenytoin sodium = mg fosphenytoin sodium. 2. Total body weight (TBW) is defined as the actual total mass of the patient in kilograms. Introduction. Fosphenytoin is a water soluble prodrug of phenytoin which is rapidly converted toFile Size: 1MB. After IV Cerebyx administration to patients with renal and/or hepatic disease, or in those with hypoalbuminemia, fosphenytoin clearance to phenytoin may be increased without a similar increase in phenytoin clearance. This has the potential to increase the . Phenytoin and now fosphenytoin are probably the most frequently used anticonvulsants for SE. The older formulation (phenytoin in a basic solution ethylene glycol) is still used because its cost is substantially lower. However, intravenous phenytoin has three major disadvantages: A longer time is required to achieve therapeutic levels.

 

Phenytoin and Fosphenytoin | Epilepsy Foundation

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